A SYMPOSIUM IN HONOR OF THE
80+ Birthday of Joachim Frank:
In Celebration of his Contributions to Cryo-EM and
Ribosome Structure, Dynamics and Function
Sunday, September 4, 2022 | 8:00 AM-7:00 PM | Vagelos Education Center, Columbia University Medical Center New York, NY
(just before the 2022 CSHL Translational Control Meeting)
![](https://static.wixstatic.com/media/24a6a1da9e7704f98ed32ece62057c60.png/v1/fill/w_980,h_613,al_c,q_90,usm_0.66_1.00_0.01,enc_auto/24a6a1da9e7704f98ed32ece62057c60.png)
![](https://static.wixstatic.com/media/c11342_5310fe4496b742be9d7b9e6029cca035~mv2.png/v1/fill/w_305,h_458,al_c,q_85,enc_auto/c11342_5310fe4496b742be9d7b9e6029cca035~mv2.png)
ABOUT
In honor of Joachim’s 80+ birthday, we invite you to join us for an all-day symposium of special speakers and presentations followed by a reception.
PROGRAM
8:00 - 9:00
Registration and Light Breakfast
CRYO-EM: PAST, PRESENT, AND FUTURE 1
9:00 - 9:10
![DeRosierDavid.png](https://static.wixstatic.com/media/c11342_e79c138d9e26452cadf0d1717db4b598~mv2.png/v1/fill/w_80,h_80,al_c,q_85,enc_auto/DeRosierDavid.png)
Chair: David DeRosier
Brandeis University
9:10 - 9:30
![ChengYifan.png](https://static.wixstatic.com/media/c11342_0a9c2c919f4b44f0954231e4fd6bac29~mv2.png/v1/fill/w_80,h_80,al_c,q_85,enc_auto/ChengYifan.png)
Yifan Cheng
University of California at San Francisco/HHMI
Single-particle cryo-EM of membrane proteins
9:30 - 9:50
![ValleMikel.png](https://static.wixstatic.com/media/c11342_caa13424bb9e462e96ca6633e30cf21e~mv2.png/v1/fill/w_80,h_80,al_c,q_85,enc_auto/ValleMikel.png)
Mikel Valle
Center for Cooperative Research in Biosciences in Bilbao
Exploring multi-pathway enzymatic reactions by cryo-EM
9:50 - 10:10
![](https://static.wixstatic.com/media/c11342_2267c0d648554a0b9846135ebbeaccf6~mv2.png/v1/fill/w_80,h_80,al_c,q_85,enc_auto/c11342_2267c0d648554a0b9846135ebbeaccf6~mv2.png)
José María Carazo
National Center for Biotechnology, CNB-CSIC, Madrid
The flexibility of biological macromolecules as revealed by cryo-EM
10:10 - 10:30
![VillaElizabeth.png](https://static.wixstatic.com/media/c11342_405879bf90944acbbddf966fe8993876~mv2.png/v1/fill/w_80,h_80,al_c,q_85,enc_auto/VillaElizabeth.png)
Elizabeth Villa
University of California in San Diego/HHMI
Opening windows into the cell: Bringing structure to cell biology using
cryo-electron tomography
10:30 - 10:55
Coffee Break
THE RIBOSOME AND TRANSLATION 1
10:55 - 11:00
![SpahnChristian.png](https://static.wixstatic.com/media/c11342_62f3d53d50af4eab9bd47b795e02ad27~mv2.png/v1/fill/w_80,h_80,al_c,q_85,enc_auto/SpahnChristian.png)
Chair: Christian Spahn
Charité, Berlin University of Medicine
11:00 - 11:20
![MoorePeter.png](https://static.wixstatic.com/media/c11342_f8aa8024f68c4a33aebea5a204a57bc0~mv2.png/v1/fill/w_80,h_80,al_c,q_85,enc_auto/MoorePeter.png)
Peter Moore
Yale University
On ribosomes and microscopes
11:20 - 11:40
![HellenChris.png](https://static.wixstatic.com/media/c11342_938f3762ae204acf9d2a432a4e9df4a8~mv2.png/v1/fill/w_80,h_80,al_c,q_85,enc_auto/HellenChris.png)
Christopher Hellen
SUNY Downstate Health Sciences University
The mechanism of initiation on the encephalomyocarditis virus IRES
11:40 - 12:00
![EhrenbergMans.png](https://static.wixstatic.com/media/c11342_741c96ea6fdd4d89b677c6ce0a9f1d6c~mv2.png/v1/fill/w_80,h_80,al_c,q_85,usm_0.66_1.00_0.01,enc_auto/EhrenbergMans.png)
Måns Ehrenberg
Uppsala University
RF3 action: A delicate truth
12:00 - 12:20
![HashemYaser.png](https://static.wixstatic.com/media/c11342_7379aa288b11468fbb2231fce48d82ff~mv2.png/v1/fill/w_80,h_80,al_c,q_85,enc_auto/HashemYaser.png)
Yaser Hashem
University of Bordeaux
Alterations in mRNA translation initiation in colorectal cancer
12:20 - 12:40
Group Picture
12:40 - 1:40
Lunch
CRYO-EM: PAST, PRESENT, AND FUTURE 2
1:40 - 1:45
![GrassucciRobert.png](https://static.wixstatic.com/media/c11342_acd28b5c96684e6091cd35ca9f7af6ab~mv2.png/v1/fill/w_80,h_80,al_c,q_85,enc_auto/GrassucciRobert.png)
Chair: Robert Grassucci
Columbia University
1:45 - 2:05
![NogalesEva.png](https://static.wixstatic.com/media/c11342_bc2ec286e5e74aee96d46888aa701912~mv2.png/v1/fill/w_80,h_80,al_c,q_85,enc_auto/NogalesEva.png)
Eva Nogales
University of California at Berkeley/HHMI
Overcoming sample preparation issues in cryo-EM
2:05 - 2:25
![SanbonmatsuKarissa.png](https://static.wixstatic.com/media/c11342_4b6677a4c9894e458bebdc49daa3cba1~mv2.png/v1/fill/w_80,h_80,al_c,q_85,enc_auto/SanbonmatsuKarissa.png)
Karissa Sanbonmatsu
Los Alamos National Laboratory
Integrating cryo-EM, single molecule FRET and molecular simulation
to elucidate the structural dynamics of the ribosome
2:25 - 2:45
![RubensteinJohn.png](https://static.wixstatic.com/media/c11342_d9d4ab95513a4294b01b4c1a4d682d42~mv2.png/v1/fill/w_80,h_80,al_c,q_85,enc_auto/RubensteinJohn.png)
John Rubinstein
The Hospital for Sick Children, Toronto
Ab initio: single particle cryoEM of the ATP synthase
2:45 - 3:05
![CarragherBridget.png](https://static.wixstatic.com/media/c11342_f84d494a02f64e29a396c8659c911a6a~mv2.png/v1/fill/w_80,h_80,al_c,q_85,enc_auto/CarragherBridget.png)
Bridget Carragher
Simons Electron Microscopy Center, New York Structural Biology Center
Time-resolved single particle EM
3:05 - 3:30
Coffee Break
THE RIBOSOME AND TRANSLATION 2
3:30 - 3:35
![HellenChris.png](https://static.wixstatic.com/media/c11342_938f3762ae204acf9d2a432a4e9df4a8~mv2.png/v1/fill/w_80,h_80,al_c,q_85,enc_auto/HellenChris.png)
Chair: Christopher Hellen
State University of New York, Downstate Health Sciences
3:35 - 3:55
![DesGeorgesAmedee.png](https://static.wixstatic.com/media/c11342_772a1e1f574b43c9a43449cf326e99de~mv2.png/v1/fill/w_80,h_80,al_c,q_85,enc_auto/DesGeorgesAmedee.png)
Amédée des Georges
City University of New York
Structure of DHX29 bound to the pre-initiation complex sheds light
on its mRNA unwinding mechanism
3:55 - 4:15
![SanyalSuparna.png](https://static.wixstatic.com/media/c11342_bce4dd69d8d946f3976b82d4f24ecedb~mv2.png/v1/fill/w_80,h_80,al_c,q_85,enc_auto/SanyalSuparna.png)
Suparna Sanyal
Uppsala University
Cryo-EM complements biochemistry to decipher the mechanism of
action of two antibiotics
4:15 - 4:35
![KieftJeffrey.png](https://static.wixstatic.com/media/c11342_386ffa256d0c47309be628b3b860bba9~mv2.png/v1/fill/w_80,h_80,al_c,q_85,enc_auto/KieftJeffrey.png)
Jeffrey Kieft
University of Colorado Anschutz Medical Campus
Structured viral RNAs that manipulate translation machinery
4:35 - 4:55
![GreenRachel.png](https://static.wixstatic.com/media/c11342_c187c5b76b894e70b46cd839358f3bd0~mv2.png/v1/fill/w_80,h_80,al_c,q_85,enc_auto/GreenRachel.png)
Rachel Green
Johns Hopkins University/HHMI
Colliding ribosomes function as a signaling hub for promoting diverse
cell fate decisions
CONCLUDING REMARKS
4:55 - 5:15
![FrankJoachim.png](https://static.wixstatic.com/media/c11342_3f7d86f5a1c140e58cdd69a733f46c84~mv2.png/v1/fill/w_80,h_80,al_c,q_85,enc_auto/FrankJoachim.png)
Joachim Frank
Columbia University
5:15 - 6:30
Reception